International Circulation: Could you please summarize the meaning of resistant hypertension for us? Dr. Markus Schlaich: We know these days that resistant hypertension is a very common problem. The prevalence of resistant hypertension is probably somewhere between 20% to 30% of patients with hypertension， so it is of clear clinical relevance. Although we don’t have clear-cut data on the prognosis， we know based on other hypertension trials that patients with resistant hypertension are at an elevated risk for cardiovascular disease. It is therefore necessary to do much more research inthat area learn more about the prevalence， the prognosis， and the factors that contribute to resistant hypertension